RESPONSE OF FACTOR XII TO DDAVP IN PATIENTS WITH HAGEMAN FACTOR DEFICIENCY
نویسندگان
چکیده
منابع مشابه
Studies on the inhibition of ellagic acid-activated Hageman factor (factor XII) and Hageman factor fragments.
Hageman factor (HF, factor XII) that has been exposed to Sephadex-ellagic acid gels is a single-chain species (HFea) with amidolytic properties for the synthetic substrate H-D-phenylalanyl-L-pipecolyl-L-arginine p-nitroanilide. Earlier we reported that amidolysis was suppressed by incubation of HFea with specific antiserum. The present study provides additional evidence that the amidolytic prop...
متن کاملThe activation of plasminogen by Hageman factor (Factor XII) and Hageman factor fragments.
Activation of plasminogen through surface-mediated reactions is well recognized. In the presence of kaolin, purified Hageman factor (Factor XII) changed plasminogen to plasmin, as assayed upon a synthetic amide substrate and by fibrinolysis. Kinetic studies suggested an enzymatic action of Hageman factor upon its substrate, plasminogen. Hageman factor fragments, at a protein concentration equiv...
متن کاملFactor XII (Hageman) Levels in Women with Recurrent Pregnancy Loss
OBJECTIVE To evaluate factor XII levels in women with recurrent pregnancy loss (RPL) in a tertiary referral hospital. METHODS Women who were referred to our hospital for two consecutive abortions or three abortions in between 2007 and 2013 were included in this retrospective observational study. Women were further grouped according to factor XII levels, as <60% and ≥ 60%. RESULTS Mean facto...
متن کاملFactor XII Deficiency
Factor XII ia a single-chain beta-globulin serine protease with a molecular weight of 80,000 84,000 daltons and a plasma concentration of approximately 30 pg/mL. Proteolytic cleavage of factor XII is mediated by charged surfaces (glass, kaolin, cellite, dextran sulfate, endotoxin, urates, crude collagen, sulfatides), autoactivation, and kallikrein. Prekallikrein, factor XI, factor VII, plasmino...
متن کاملHageman trait (factor XII deficiency): a probably second genotype inherited as an autosomal dominant characteristic.
A family is described in which HageImmunologic studies suggested that man trait appeared to be inherited in the molecular defect was similar to an autosomal dominant manner in that of the autosomal recessive form contrast to previously reported families and consisted of deficiency of antiin which the disorder behaves as an gens related to Hageman factor. autosomel recessive characteristic. H AG...
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ژورنال
عنوان ژورنال: British Journal of Haematology
سال: 1983
ISSN: 0007-1048,1365-2141
DOI: 10.1111/j.1365-2141.1983.tb02856.x